Holger Blume (born 28 December 1973 in Lüdinghausen) is a German sprinter who specializes in the 100 metres.
He is the twin brother of Marc Blume. Both represent the sports club TV Wattenscheid.
Holger Blume finished seventh in 4 x 100 metres relay at the 1998 IAAF World Cup, with teammates Patrick Schneider, Manuel Milde and Marc Blume. He also participated in this event at the 1996 Olympic Games, the 1999 World Championships and the 2002 IAAF World Cup without reaching the final.